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产品中心 药物靶点和Fc受体 药物靶点

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IL-18BP His Tag Protein, Human

IL18BP,IL18BPa,Tadekinig-alfa

价格 ￥1,587.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010574
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 抗原名称

    IL-18BP

  • 分子别名

    IL18BP, IL18BPa, Tadekinig-alfa

  • Accession

    O95998-2

  • 表达序列

    Thr31-Gly194, with C-terminal 8*His TPVSQTTTAATASVRSTKDPCPSQPPVFPAAKQCPALEVTWPEVEVPLNGTLSLSCVACSRFPNFSILYWLGNGSFIEHLPGRLWEGSTSRERGSTGTQLCKALVLEQLTPALHSTNFSCVLVDPEQVVQRHVVLAQLWAGLRATLPPTQEALPSSHSSPQQQGGGGSHHHHHHHH

  • 表达宿主

    HEK293

  • 分子量

    40-50kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Review Front ImmunoQl . 2013 Oct 8;4:289.

背景介绍

  • Interleukin-18 binding protein, also known as IL-18BP and tadekinig-alfa, is a secreted glycoprotein that contains an Ig-like C2-type domain. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. IL18BP shares many characteristics with soluble cytokine receptors of the IL1 family in that the protein exhibits specificity for IL18, belongs to the immunoglobulin-like class of receptors and has limited amino acid sequences with those of the IL1 receptor type II. According to the other study, IL1R9 is evolutionarily related to IL18BP and may function as an IL-18 receptor. Plasma il-18 /IL18BP levels increase during disease activity, suggesting that it may play a role in the pathogenesis of ITP.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

  • ELISA

    • Immobilized IL-18, Human (Cat. No. UA040111) at 2.0μg/mL (100μL/well) can bind IL-18BP His Tag, Human (Cat. No. UA010574) with EC50 of 0.68-0.91ng/ml.

    • Measured by its ability to inhibit the IL-18-induced response of KG-1 human acute myelogenous leukemia cells. The IC50 for this effect is 9.3-13 ng/mL in the presence of 20 ng/mL of recombinant human IL-18.

  • SPR

    • Anti-His antibody Immobilized on CM5 Chip captured IL-18BP His Tag, Human (Cat. No. UA010574), can bind IL-18, Human Cat. No. UA040111) with an affinity constant of 3.15nM as determined in SPR assay.

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