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产品中心 药物靶点和Fc受体 药物靶点

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CD155/PVR Fc Chimera Protein, Mouse

FLJ25946,PVS,TAGE4,HVED,NECL5

价格 ￥2,450.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010572
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Mouse

  • 抗原名称

    CD155/PVR

  • 分子别名

    FLJ25946, PVS, TAGE4, HVED, NECL5

  • Accession

    Q8K094

  • 表达序列

    Asp29-Leu348, with C-terminal Human IgG1 Fc

  • 表达宿主

    HEK293

  • 分子量

    75-95kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Liu Lu ,Wang Ying ,Geng Chen,Wang Aihong ,Han Sai ,You Xuewu ,Sun Yu ,Zhang Junhua ,Lu Wei ,Zhang Youzhong. CD155 Promotes the Progression of Cervical Cancer Cells Through AKT/mTOR and NF-kappa B Pathways. [J] FRONTIERS IN ONCOLOGY.2021-07-05(11).

背景介绍

  • CD155 is a member of the immunoglobulin superfamily also known as the human receptor for poliovirus (PVR). The full length (or PVR alpha isoform) is synthesized as a 417 amino acid (aa) precursor that contains a 20aa signal sequence, a 323aa extracellular region, a 24aa TM segment and a 50aa cytoplasmic tail. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhesion, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity. CD155 is expressed at high levels in several human malignancies and seems to have pro tumorigenic and therapeutically attractive properties that are currently being investigated in the field of recombinant oncolytic viro therapy.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

  • ELISA

    • Immobilized TIGIT His Tag, Mouse (Cat. No. UA010084) at 2.0μg/mL (100μL/well) can bind CD155/PVR Fc Chimera, Mouse (Cat. No. UA010572) with EC50 of 0.13-0.19μg/mL .

  • 分子互作

    • Protein A Chip captured CD155/PVR Fc Chimera, Mouse (Cat. No. UA010572), can bind . TIGIT His Tag, Mouse (Cat. No. UA010084) with an affinity constant of 1.46μM as determined in SPR assay.

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