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产品中心 药物靶点和Fc受体 药物靶点

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GUCY2C His Tag Protein, Mouse

Intestinal guanylate cyclase,Hstar,EC:4.6.1.2,EC 4.6.1,GC-C

价格 ￥2,780.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010570
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Mouse

  • 分子别名

    Intestinal guanylate cyclase,Hstar,EC:4.6.1.2,EC 4.6.1,GC-C

  • Accession

    Q3UWA6

  • 表达序列

    Val20-Met433, with C-terminal 8*His

  • 表达宿主

    HEK293

  • 分子量

    75-95kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Arshad N. et al. (2013) Site-specific N-Linked Glycosylation of Receptor Guanylyl Cyclase C Regulates Ligand Binding, Ligand-mediated Activation and Interaction with Vesicular Integral Membrane Protein 36. J. Biol. Chem. 288(6):3907-3917. 2. Gibbons A V. et al. (2013) Intestinal GUCY2C Prevents TGF-β Secretion Coordinating Desmoplasia and Hyperproliferation in Colorectal Cancer. Cancer Res.73(22): 6654-6666.

背景介绍

  • Guanylyl Cyclase C (GUCY2C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (GC) family expressed by intestinal epithelial cells from the duodenum to rectum. Mature human GUCY2C consists of an extracellular domain (ECD) with a ligand binding domain, a transmembrane segment and a cytoplasmic region possessing a kinase and GC catalytic domain. Endogenous ligands of GUCY2C include guanylin and uroguanylin. GUCY2C in epithelial cells plays an important role in cell dynamics and homeostatic balance of proliferation, metabolism, and differentiation that organizes the guanylyl cyclase C hormone axis. GUCY2C is also expressed in the brain and is implicated in attention deficiency and hyperactive behavior. The activation of cyclic guanosine monophosphate (cGMP), a second intracellular messenger, can stimulate the production of cyclic guanosine monophosphate (CGMP), which plays a role in regulating homeostasis, maintaining intestinal barrier function, and exerting anti-inflammatory activity.

  • 电泳

    • 1ug (R: reducing conditions, N: non-reducing conditions).

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