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产品中心 药物靶点和Fc受体 药物靶点

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DNAM-1/CD226 Fc Chimera Protein, Human

PTA1

价格 ￥2,300.00 （ 1-2周）
货号 UA010560
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 抗原名称

    DNAM-1/CD226

  • 分子别名

    PTA1

  • Accession

    Q15762

  • 表达序列

    Glu19-Asn247, with C-terminal Human IgG1 Fc

  • 表达宿主

    HEK293

  • 分子量

    70-75kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. WANG, MENGJIE, BU, JIN, ZHOU, MAOHUA, et al. CD8(+) T cells expressing both PD-1 and TIGIT but not CD226 are dysfunctional in acute myeloid leukemia (AML) patients[J]. Clinical immunology: The official journal of the Clinical Immunology Society,2018,19064-73.

背景介绍

  • DNAM-1 is a member of the Ig superfamily, encoded by a gene on human chromosome 18q22.3, is expressed by human NK cells, T cells, a subset of B cells, monocytes and platelets. Interactions between DNAM-1 on NK cells and its ligands on tumour cells augments the NK cell–mediated cytotoxicity and cytokine production. CD155 and its related family member CD112, the known ligands for DNAM-1, broadly expressed on hematopoietic, epithelial, and endothelial cells. Moreover, it was shown that the interaction of DNAM-1 with CD112 and CD155 contributes to the NK-mediated lysis of both imDCs and mDCs. Dysregulation of DNAM-1 is associated with susceptibility to juvenile idiopathic arthritis, type 1 diabetes (T1D), lupus, and rheumatoid arthritis in patients.

  • 电泳

    • 1ug (R: reducing conditions, N: non-reducing conditions).

  • ELISA

    • Immobilized CD155/PVR His Tag, Human (Cat. No. UA010069) at 2.0μg/mL (100μL/well) can bind DNAM-1/CD226 Fc Chimera, Human (Cat. No. UA010560) with EC50 of 4.48-13.43μg/ml.

  • SPR

    • Protein A Chip captured DNAM-1/CD226 Fc Chimera, Human(Cat. No. UA010560), can bind CD155/PVR His Tag, Human(Cat. No. UA010069) with an affinity constant of 1.28μM as determined in SPR assay.

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