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产品中心 药物靶点和Fc受体 药物靶点

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Frizzled-10/FZD10 Fc Chimera Protein, Human

CD350 antigen,CD350,frizzled (Drosophila) homolog 10,frizzled homolog 10 (Drosophila),Frizzled10,Frizzled-10,Fz10,FZ-10,FZD10,FzE7,hFz10

价格 ￥2,079.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010552
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 抗原名称

    Frizzled-10/FZD10

  • 分子别名

    CD350 antigen, CD350, frizzled (Drosophila) homolog 10, frizzled homolog 10 (Drosophila), Frizzled10, Frizzled-10, Fz10, FZ-10, FZD10, FzE7, hFz10

  • Accession

    Q9ULW2Y

  • 表达序列

    Ile21-Gly161, with C-terminal Human IgG Fc

  • 表达宿主

    HEK293

  • 分子量

    50-55kDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1． Cell Signal . 2006 Jul;18(7):934-41. Epub 2006 Feb 9.

背景介绍

  • Frizzled-10 (FZD10), also known as CD350, is a G-protein coupled receptor with seven transmembrane domains. The 205 amino acid N-terminal extracellular region of Frizzled-10 contains a cysteine-rich domain that comprises the Wnt binding domain and mediates receptor oligomerization. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. Frizzled-10 is also up-regulated in several cancers and transformed cell lines. It may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and differentiation.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

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