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产品中心 药物靶点和Fc受体 药物靶点

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Tie-2 Fc Chimera Protein, Cynomolgus

TIE2,Tie-2,TEK,VMCM,VMCM1,CD202b,Angiopoietin-1 receptor

价格 ￥2,450.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010526
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Cynomolgus

  • 抗原名称

    Tie-2

  • 分子别名

    TIE2, Tie-2, TEK, VMCM, VMCM1, CD202b, Angiopoietin-1 receptor

  • Accession

    G7PS68

  • 表达序列

    Ala23-Lys745, with C-terminal Human IgG1 Fc

  • 表达宿主

    HEK293

  • 分子量

    113-128kDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Jones N. et al. (1998) The Tek / Tie2 receptor signals through a novel Dok-related docking protein, Dok-R. Oncogene. 17(9): 1097-1108.2.Sato A. et al. (1998) Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells. Int Immunol. 10(8): 1217-1227.

背景介绍

  • Tie-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis.

  • 生物活性

    • Protein A Chip captured Tie-2 Fc Chimera, Cynomolgus (Cat. No. UA010526), can bind Angiopoietin-2(275-496) His Tag, Human(Cat. No. UA010220) with an affinity constant of 0.93μM as determined in SPR assay.

    • Immobilized Angiopoietin-2(275-496) His Tag, Human (Cat. No. UA010220) at 2.0μg/mL (100μL/well) can bind Tie-2 Fc Chimera, Cynomolgus (Cat. No. UA010526) with EC50 of 0.22-0.55μg/ml.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

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