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产品中心 药物靶点和Fc受体 药物靶点

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TrkA/NTRK1 Fc Chimera Protein, Mouse

MTC,TRK,TRKA

价格 ￥3,020.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010520
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Mouse

  • 抗原名称

    TrkA/NTRK1

  • 分子别名

    MTC, TRK, TRKA

  • Accession

    Q3UFB7

  • 表达序列

    Ala34-Gly420, with C-terminal Human IgG1 Fc

  • 表达宿主

    HEK293

  • 分子量

    95-120kDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Harrington, A. et al. (2011) Cell. 146(3):421.2.Smeyne, R. et al. (1994) 368(6468):246.3.Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival. Harrington A.W., St Hillaire C., Zweifel L.S., Glebova N.O., Philippidou P., Halegoua S., Ginty D.D.4.Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Smeyne R.J., Klein R., Schnapp A., Long L.K., Bryant S., Lewin A., Lira S.A., Barbacid M.5.TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo. Fagan A.M., Zhang H., Landis S., Smeyne R.J., Silos-Santiago I., Barbacid M.

背景介绍

  • Tropomyocin receptor kinase A (TrkA), also named Neurotrophic tyrosine kinase receptor type 1 (NTRK3) is a member of a nerve growth factor tyrosine kinase receptor family. There are three members of the Trk family, TrkA, TrkB and TrkC, and they bind a group of structurally related, secreted proteins termed neurotrophins, which play an important role in the development and function of the nervous system. Each Trk family member exhibits different ligand specificities: TrkA binds NGF and NT-3, TrkB binds BDNF, NT-3 and NT-4/5, and TrkC only binds NT-3. The biological activities of the neurotrophins are mediated by binding to and activating two unrelated receptor types: the p75 neurotrophin receptor (p75NTR) and the Trk family receptors. P75NTR is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and has been designated TNFRSF16.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

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