uPAR/CD87 His Tag Protein, Human
Monocyte activation antigen Mo3,U-PAR,uPAR,Urokinase-Type Plasminogen Activator (UPA) Receptor,URKR,U-Plasminogen Activator Receptor Form 2,CD87 Antigen,Plasminogen Activator,Urokinase Receptor,MO3
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物种
Human分子别名
Monocyte activation antigen Mo3, U-PAR, uPAR, Urokinase-Type Plasminogen Activator (UPA) Receptor, URKR, U-Plasminogen Activator Receptor Form 2, CD87 Antigen, Plasminogen Activator, Urokinase Receptor, MO3Accession
Q03405表达序列
Leu23-Gly305 with His Tag at C-Terminus
表达宿主
HEK293分子量
43-55kDa (Reducing)
纯度
> 95% by SDS-PAGE &RP-HPLC内毒素含量
<0.1EU/μg活性
CM5 Chip captured uPAR/CD87 His Tag Protein, Human (Cat. No. UA010519), can bind Human PLAU / uPA Protein, His Tag with an affinity constant of 0.12nM as determined in SPR assay.标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
PBS, PH7.4
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1.Desmedt, S. et al. (2017) Crit. Rev. Clin. Lab. Sci. 54:117.2.Smith, H. et al. (2010) Nat Rev Mol Cell Biol 11:23.
Urokinase plasminogen activator surface receptor (U-PAR), also known as PLAUR, Monocyte activation antigen Mo3, or CD87, is a key player in cellular processes involving migration and tissue remodeling. It binds to urokinase-type plasminogen activator (uPA), which converts plasminogen to plasmin, a serine protease essential for normal and pathological cell migration and tissue destruction. uPA is initially released as a single-chain pro-enzyme (scuPA) with low activity and is activated to a two-chain form (tcuPA) by plasmin and other proteinases. Both forms of uPA bind to uPAR, localizing uPA's proteolytic activity and enhancing its enzymatic activity.The uPA/uPAR interaction initiates signal transduction, activating protein tyrosine kinases, influencing gene expression, and promoting cell adhesion and chemotaxis. uPAR can also modulate integrin function, suppressing normal adhesion while enhancing vitronectin binding through its high-affinity site. This interaction is significant in various inflammatory diseases, including cancer, cardiovascular diseases, chronic kidney diseases, and diabetes, making uPAR a potential biomarker for these conditions
电泳
1μg (R: reducing condition, N: non-reducing condition).
反相高效液相色谱(RP-HPLC)
The purity of uPAR/CD87 His Tag Protein, Human more than 95% as determined by RP-HPLC.
SPR
CM5 Chip captured uPAR/CD87 His Tag Protein, Human (Cat. No. UA010519), can bind Human PLAU / uPA Protein, His Tag with an affinity constant of 0.12nM as determined in SPR assay.
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