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EPCR/PROCR His Tag Protein, Mouse

Endothelial cell protein C receptor,Activated protein C receptor,APC receptor,EPCR,PROCR,CD201

价格 ￥4,950.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010516
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Mouse

  • 抗原名称

    EPCR/PROCR

  • 分子别名

    Endothelial cell protein C receptor, Activated protein C receptor, APC receptor, EPCR, PROCR, CD201

  • Accession

    Q64695

  • 表达序列

    Leu18-Ser214, with C-terminal 8*His

  • 表达宿主

    HEK293

  • 分子量

    33-43kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Montes, R. et al. (2012) Thromb. Haemost. 107:815. 2. Bae, J.-S. et al. (2007) Blood 110:3909. 3. Fink, K. et al. (2013) PLoS One 8:e53103. 4. Willcox, C.R. et al. (2012) Nat. Immunol. 13:872. 5. Turner, L. et al. (2013) Nature 498:502.

背景介绍

  • The endothelial protein C receptor (EPCR), also known as CD201, is an approximately 50 kDa transmembrane glycoprotein expressed on vascular endothelial cells and functions as a negative regulator of thrombosis. EPCR inhibits thrombosis through its interactions with Protein C, activated Protein C (APC), and Coagulation Factors VII, and VIIa. It enhances the activation of Protein C in response to complexes of Thrombin-Thrombomodulin. In humans, a soluble form of EPCR can be produced by alternative splicing or ADAM17/TACE mediated shedding, and this protein inhibits the anti-coagulant activity of APC. EPCR can be degraded on the surface of endothelial cells by Neutrophil Elastase. Activation of EPCR also protects vascular endothelial cells from Thrombin-induced apoptosis. EPCR binds to CD11b/CD18 (Mac-1) on monocytes and mediates monocyte adhesion to the vascular endothelium. In addition, EPCR binds to the antigen receptor on gamma δ T cells, promotes hematopoietic stem cell retention in the bone marrow, and binds to surface proteins of some species of Plasmodium, contributing to pathogenicity in severe malaria.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

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