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产品中心 药物靶点和Fc受体 药物靶点

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CD140b/PDGFRB His Tag Protein, Human

J03278,M21616,JTK12,pdgf-r-β

价格 ￥2,050.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010514
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 抗原名称

    CD140b/PDGFRB

  • 分子别名

    J03278, M21616, JTK12, pdgf-r-β

  • Accession

    P09619

  • 表达序列

    Leu33-Val532, with C-terminal 10*His

  • 表达宿主

    HEK293

  • 分子量

    75-95kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. RAMESH PERIASAMY, SALLY L. ELSHAER, RAJASHEKHAR GANGARAJU. CD140b (PDGFRp) Signaling in Adipose-Derived Stem Cells Mediates Angiogenic Behavior of Retinal Endothelial Cells.[J]. Regenerative engineering and translational medicine,2019,5(1):1-9.

背景介绍

  • Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB) is receptor that binds specifically to PDGFB. It is characterized by the presence of five immunoglobulin- like domains in their extracellular region and a split kinase domain in their intracellular region. The extracellular domain of human PDGF R beta contains 4 disulfide bonds and shares a 79% sequence identity with mouse and rat PDGF R beta. It is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor (PDGF) family. Recombinant soluble PDGFRB binds PDGF with high affinity and is potent PDGF antagonist.Many cell types, including fibroblasts and smooth muscle cells, express both the alpha and beta receptors.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

  • ELISA

    • Immobilized PDGF-BB, Human (Cat. No. UA040014) at 0.5μg/mL (100μL/well) can bind CD140b/PDGFRB His Tag, Human (Cat. No. UA010514) with EC50 of 35.14-52.62 ng/mL.

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