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物种
Human抗原名称
TNFRSF10B/TRAIL R2分子别名
TRAIL-R2, CD262, DR5, KILLER, TRICK2, ZTNFR9, TRICKBAccession
O14763表达序列
Ile56-Glu182, with C-terminal Human IgG Fc表达宿主
HEK293分子量
40-45kDa纯度
＞95% by SDS-PAGE内毒素含量
<0.1EU/μg标记
Unconjugated标签
Human Fc性状
Lyophilized Powder缓冲体系
PBS, pH7.4溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1. Walczak, H. et al. (1997) EMBO J. 16:5386.
TNFRSF10B, also called TRAIL R2 and DR5, is a member of the TNF receptor superfamily. TRAIL-R2 contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. Human and mouse TRAIL R2 share 49% amino acid sequence similarity. Some studies have suggested that TNFRSF10B contributes more than TNFRSF10A (TRAIL R1) to TRAIL-induced apoptosis in cancer cells that express both receptors. In addition, agonistic monoclonal antibodies against TNFRSF10B, which can induce apoptosis in the absence of TRAIL, are used for cancer therapies.
电泳
1μg (R: reducing condition, N: non-reducing condition).
SPR
Protein A Chip captured TNFRSF10B/TRAIL R2 Fc Chimera, Human(Cat. No. UA010513), can bind TRAIL/Apo2L, Human(Cat. No. UA040039) with an affinity constant of 25.85pM as determined in SPR assay.
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