热搜词：
注册
登录
CN
  • CN
  • EN

产品中心 药物靶点和Fc受体 药物靶点

所有图片（1/3）

CD200R His Tag Protein, Human

Cell surface glycoprotein OX2 receptor 1,CD200 cell surface glycoprotein receptor

价格 ￥3,020.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010500
规格
数量
收藏 分享
产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human, Human

  • 抗原名称

    CD200R

  • 分子别名

    Cell surface glycoprotein OX2 receptor 1，CD200 cell surface glycoprotein receptor

  • Accession

    Q8TD46

  • 表达序列

    Ala27-Leu266, with C-terminal 8*His

  • 表达宿主

    HEK293

  • 分子量

    45-70kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Rosenblum, M.D. et al. (2006) J. Dermatol. Sci. 41:165.2. Gorczynski, R.M. (2005) Curr. Opin. Invest. Drugs 6:483. 3. Barclay, A.N. et al. (2002) Trends Immunol. 23:285.

背景介绍

  • CD200 R1, also known as OX-2 receptor, is a 90 kDa, type I transmembrane protein that belongs to the immunoglobulin superfamily. CD200 R1 is important in the regulation of myeloid cell activity.CD200 and its receptor CD200R are both type-1 membrane glycoproteins, which are members of the immunoglobulin superfamily (IgSF). Besides the inhibitory effect on macrophages, CD200/CD200R also play an important role in regulating the regulatory T cells, allergic reaction, autoimmune diseases, allograft, neurological diseases and other autoimmune-related diseases. The interaction between CD200, which is mainly present in neurons but also in astrocytes, and CD200R1, which is mainly present in microglia, is one of the mechanisms involved in keeping the microglial proinflammatory phenotype under control in physiological conditions. Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

  • ELISA

    • Immobilized CD200R His Tag, Human (Cat. No. UA010500) at 0.5μg/mL (100μL/well) can bind CD200 Fc Chimera, Human (Cat. No. UA010512) with EC50 of 2.29-3.65ng/ml.

  • SPR

    • Protein A Chip captured CD200 Fc Chimera, Human (Cat. No. UA010512), can bind CD200R His Tag, Human(Cat. No. UA010500) with an affinity constant of 29.98nM as determined in SPR assay.

评论(0)