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产品中心 药物靶点和Fc受体 药物靶点

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BMPRIA/ALK-3 Fc Chimera Protein, Human

BMP type-1A receptor,BMPR-1A,Activin receptor-like kinase 3 (ALK-3) Serine/threonine-protein kinase receptor R5 (SKR5)

价格 ￥2,360.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010496
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 抗原名称

    ALK-3/BMPRIA

  • 分子别名

    BMP type-1A receptor, BMPR-1A, Activin receptor-like kinase 3 (ALK-3) Serine/threonine-protein kinase receptor R5 (SKR5)

  • Accession

    P36894

  • 表达序列

    Gln24-Arg152, with C-terminal Human IgG1 Fc

  • 表达宿主

    HEK293

  • 分子量

    45-53 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2878-83. Epub 2002 Feb 19.
    2. Gorczynski, R.M. (2005) Curr. Opin. Invest. Drugs 6:483. 3. Barclay, A.N. et al. (2002) Trends Immunol. 23:285.

背景介绍

  • Activin receptor-Like Kinase 3 (ALK-3), also known as Bone Morphogenetic Protein Receptor, type IA (BMPR1A), is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta (TGF-β) superfamily. The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. ALK-3 plays an essential role in the formation of embryonic ventral abdominal wall, and abrogation of BMP signaling activity due to gene mutations in its signaling components could be one of the underlying causes of omphalocele at birth.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

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