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产品中心 药物靶点和Fc受体 药物靶点

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Cadherin-1/CDH1 His Tag Protein, Human

CAM 120/80,Epithelial cadherin (E-cadherin),Uvomorulin

价格 ￥2,600.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010495
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 抗原名称

    Cadherin-1/CDH1

  • 分子别名

    CAM 120/80, Epithelial cadherin (E-cadherin), Uvomorulin

  • Accession

    P12830

  • 表达序列

    Asp155-Ala709, with C-terminal 10*His

  • 表达宿主

    HEK293

  • 分子量

    73-81kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Nelson WJ. Regulation of cell-cell adhesion by the cadherin-catenin complex. Biochem Soc Trans. 2008 Apr;36(Pt 2):149-55.
    2. Gumbiner BM. Regulation of cadherin adhesive activity. J Cell Biol. 2000 Feb 7;148(3):399-404.

背景介绍

  • CDH1 (also known as epithelial cadherin (E-cadherin), a member of the cadherin- catenin complex, is an example in which pathogenic variants can lead to CLP and/or gastric cancer. The human CDH1 gene consists of 16 exons that span 100 kb. Classical cadherins are a family of single-span transmembrane domain glycoproteins that primarily mediate calcium-dependent cell–cell adhesion, which are differentially expressed throughout the body. Cadherins are single-membrane-spanning proteins with a divergent extracellular domain of five repeats and a conserved cytoplasmic domain. Much experimental evidence suggests that the CDH1 is a tumor suppressor and alterations in its expression are linked with multiple tumor types and its clinicopathological features. Loss of CDH1 is used for the diagnosis and prognosis of epithelial cancers.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

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