热搜词：
注册
登录
CN
  • CN
  • EN

产品中心 药物靶点和Fc受体 药物靶点

所有图片（1/1）

OSMR/IL-31RB His Tag Protein, Human

OSMRB,PLCA1,IL-31RB,OSMR beta,IL-31R-beta

价格 ￥2,450.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010488
规格
数量
收藏 分享
产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 抗原名称

    OSMR/IL-31RB

  • 分子别名

    OSMRB,PLCA1, IL-31RB,OSMR beta,IL-31R-beta

  • Accession

    Q99650

  • 表达序列

    Glu28-Met740, with C-terminal 10*His

  • 表达宿主

    HEK293

  • 分子量

    100-120 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Qing Guo, Ge‐fei Guan, Jing‐yuan Cao, Cun‐yi Zou, Chen Zhu, Wen Cheng. Overexpression of oncostatin M receptor regulates local immune response in glioblastoma. OR IGINAL RESEARCH ARTICLE.

背景介绍

  • Oncostatin M receptor (OSMR), also named as IL‐31R‐β, is a cytokine receptor gene of IL‐6 family and transduces oncostatin M (OSM) and IL‐31 signaling. A recent study shows that OSMR expression is elevated in GBM, especially mesenchymal subtype. OSM/OSMR signaling has been shown to play an important role in driving the glioma cells towards mesenchymal type, and correlated with poor survival. Moreover, OSMR is a direct transcriptional target gene of STAT3 and forms a physical complex with epidermal growth factor receptor vIII (EGFRvIII), a truncated EGFR in which exons 2−7 are deleted. OSMR also promotes the proliferation of human brain tumor stem cells (BTSCs) and the depletion of OSMR impaired EGFRvIII‐STAT3 signaling. OSMR may be a key factor and related to JAK/STAT signaling in mediating the effect of endogenous bornavirus‐like nucleoprotein elements on the proliferation and apoptosis of oligodendroglia cells.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

评论(0)