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产品中心 药物靶点和Fc受体 药物靶点

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EMMPRIN/CD147 Fc Chimera Protein, Human

hEMMPRIN,Basigin,BSG,5F7,CD147,EMMPRIN,M6,OK,TCSF

价格 ￥3,020.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010478
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human, Human

  • 抗原名称

    EMMPRIN/CD147

  • 分子别名

    hEMMPRIN, Basigin, BSG, 5F7, CD147, EMMPRIN, M6, OK, TCSF

  • Accession

    Q54A51

  • 表达序列

    Ala22-His205 , with C-terminal Human IgG1 Fc

  • 表达宿主

    HEK293

  • 分子量

    57-70 kDa(Reducing)

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Gabison, E. E. et al. (2005) Biochimie 87:361.2. Yurchenko, V. et al. (2006) Immunology 117:301.3. Kasinrerk, W. et al. (1992) J. Immunol. 149:847.4. Iacono, K.T. et al. (2007) Exp. Mol. Pathol. 83:283.

背景介绍

  • Extracellular matrix metalloproteinase (MMP) inducer (EMMPRIN), also known as basigin and CD147, is a 44-66 kDa, variably N- and O-glycosylated, type I transmembrane protein that belongs to the immunoglobulin superfamily. EMMPRIN belongs to the immunoglobulin (Ig) superfamily and is composed of two C2-like immunoglobulin extracellular domains, a transmembrane domain and a short cytoplasmic domain. The extracellular region, which contains three conserved N-glycosylation sites that are variably glycosylated, has been implicated in EMMPRIN self association, while the first Ig domain within this region is required for counter-receptor activity involved in MMP induction. The highly conserved transmembrane domain and the short cytoplasmic domain are thought to be implicated in interactions between EMMPRIN and other molecular partners within the membrane. In particular, EMMPRIN was shown to interact with integrins α3β1 and α6β1, enhancing the adhesion and spreading of the cell to the ECM and to caveolin-1 in lipid rafts leading to a decrease in EMMPRIN cell surface self association.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

  • ELISA

    • Immobilized EMMPRIN/CD147 Fc Chimera, Human (Cat. No. UA010478) at 2.0μg/mL (100μL/well) can bind CD147 Recombinant Rabbit mAb (SDT-681-18) (Cat. No. S0B2290) with EC50 of 2.26-4.23ng/mL.

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