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物种
Mouse抗原名称
BTNL2分子别名
rMuBTNL2, Butyrophilin-like protein 2Accession
O70355表达序列
Lys24-Trp454, with C-terminal 8*His表达宿主
HEK293分子量
55-65kDa纯度
＞95% by SDS-PAGE内毒素含量
<0.1EU/μg标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1. Arnett, H.A. et al. (2007) J. Immunol. 178:1523. 2. Arnett, H.A. et al. (2009) Cytokine 46:370. 3. Smith, I.A. et al. (2010) J. Immunol. 184:3514. 4. Nguyen, T. et al. (2006) J. Immunol. 176:7354.
Butyrophilin-like 2 (BTNL2) is a member of the BTN/MOG Ig-superfamily and functions as a negative regulator of immune cell activation. BTNL2 is expressed in epithelial cells of the small intestine, colonic dendritic cells, and in cells of the lymph node. BTNL2 expression is upregulated in T cells following activation, a characteristic BTNL2 shares with the homologous B7 family of co-stimulatory molecules. BTNL2 negatively regulates T cells by inhibiting proliferation and inflammatory cytokine secretion. It also increases the expression of FoxP3 in T cells to promote regulatory T cell development. Single nucleotide polymorphisms in BTNL2 are associated with a risk for sporadic prostate cancer, rheumatoid arthritis, sarcoidosis, ulcerative colitis, and other inflammatory diseases.
电泳
1μg (R: reducing conditions, N: non-reducing conditions).
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