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产品中心 药物靶点和Fc受体 药物靶点

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TWEAKR/TNFRSF12A Fc Chimera Protein, Human

TNFRSF12A,FGF-inducible 14,FN14,TweakR,CD266

价格 ￥3,020.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010454
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 抗原名称

    TWEAKR/TNFRSF12A

  • 分子别名

    TNFRSF12A,FGF-inducible 14,FN14,TweakR,CD266

  • Accession

    Q9NP84

  • 表达序列

    Glu28-Trp79,with N-terminal Human IgG Fc

  • 表达宿主

    HEK293

  • 分子量

    33-35kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Feng, S. et al. (2000) Am J. Pathol.156:1253.

背景介绍

  • TNFRSF12A was initially identified as a fibroblast growth factor-1-inducible gene in murine NIH 3T3 cells, and was named as fibroblast growth factor-inducible-14 (Fn14) gene. Human TNFRSF12A was cloned from a HUVEC cDNA library and identified as the TWEAK receptor and a member of the TNFR family. TNFRSF12A is highly expressed in heart, placenta and kidney. TNFRSF12A / FN14 promotes angiogenesis and the proliferation of endothelial cells. TNFRSF12A and its ligand play a key role in muscle atrophy, cerebral ischemia, kidney injury, atherosclerosis, experimental autoimmune encephalitis, rheumatoid arthritis, and inflammatory bowel disease.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

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