热搜词：
注册
登录
CN
  • CN
  • EN

产品中心 药物靶点和Fc受体 药物靶点

所有图片（1/3）

TNFSF11/RANKL Fc Chimera Protein, Human

RANKL,CD254,TRANCE,OPGL,ODF

价格 ￥4,320.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010453
规格
数量
收藏 分享
产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 抗原名称

    TNFSF11/RANKL

  • 分子别名

    RANKL,CD254,TRANCE,OPGL,ODF

  • Accession

    O14788-2

  • 表达序列

    Gly63-Asp244, with N-terminal Human IgG Fc

  • 表达宿主

    HEK293

  • 分子量

    55-60kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.O'Brien, C.A. (2010) Bone 46, 911-9.


背景介绍

  • RANKL (also known as TRANCE or OPGL) is a member of the TNF ligand superfamily. RANKL is produced by T cells, mammary epithelial cells and endothelial cells. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. RANK and RANKL are key regulators of bone remodeling and regulate T cell/dendritic cell communications, and lymph node formation.RANK-RANKL signaling not only activates a variety of downstream signaling pathways required for osteoclast development, but crosstalk with other signaling pathways also fine-tunes bone homeostasis both in normal physiology and disease.

  • 生物活性

    • Measured by its ability to induce osteoclast differentiation of RAW 264.7 mouse monocyte/macrophage cells.The EC50 for this effect is less than 5ng/ml.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • ELISA

    • Immobilized Osteoprotegerin/TNFRSF11B His Tag Protein, Human (Cat. No.UA011378) at 10.0μg/mL (100μL/well) can bind TNFSF11/RANKL Fc Chimera Protein, Human (Cat. No. UA010453) with EC50 of 2.28-2.78 ng/mL.

评论(0)