热搜词：
注册
登录
CN
  • CN
  • EN

产品中心 药物靶点和Fc受体 药物靶点

所有图片（1/1）

TrkA/NTRK1 His Tag Protein, Human

MTC,TRK,TRKA

价格 ￥3,020.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010451
规格
数量
收藏 分享
产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 抗原名称

    TrkA/NTRK1

  • 分子别名

    MTC, TRK, TRKA

  • Accession

    P04629

  • 表达序列

    Ala33-Gly423, with C-terminal 8*His

    AAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGGGGSHHHHHHHH

  • 表达宿主

    HEK293

  • 分子量

    72-90kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Nathan Griffin, Mark Marsland, Severine Roselli. The Receptor Tyrosine Kinase TrkA Is Increasedand Targetable in HER2-Positive Breast Cancer. Biomolecules 2020, 10


背景介绍

  • The tyrosine kinase receptor TrkA (or neurotrophin receptor kinase 1, NTRK1) has been predominately studied for its role during the development of the nervous system. In developing neurons, TrkA activation upon binding of its ligands nerve growth factor (NGF) or neurotrophin-3(NT-3) results in the stimulation of various tyrosine kinase-induced signaling pathways leading to neuronal outgrowth. In the adult, where neurogenesis is largely reduced, TrkA acts as a pain receptor in sensory neurons and contributes to the transmission of pain signals to the central nervous system. Interestingly, TrkA is also oncogenic and there is accumulating evidence for its overexpression and involvement in cancer progression , including in the form of TrkA fusion proteins as described in lung cancer. Furthermore, TrkA is a therapeutic target in oncology and Trk inhibitors are being tested in several clinical trials.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

评论(0)