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产品中心 药物靶点和Fc受体 药物靶点

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BTNL2 mFc Chimera Protein, Mouse

BTL-II,Butyrophilin like 2,butyrophilin-like 2 (MHC class II associated),Butyrophilin-like 2

价格 ￥2,970.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010450
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Mouse

  • 抗原名称

    BTNL2

  • 分子别名

    BTL-II; Butyrophilin like 2; butyrophilin-like 2 (MHC class II associated); Butyrophilin-like 2

  • Accession

    O70355

  • 表达序列

    Lys24-Trp454, with C-terminal Mouse mIgG2a Fc

  • 表达宿主

    HEK293

  • 分子量

    72-95kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Mouse Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Arnett, H.A. et al. (2007) J. Immunol. 178:1523.

    2.Arnett, H.A. et al. (2009) Cytokine 46:370.

    3.Smith, I.A. et al. (2010) J. Immunol. 184:3514.

    4.Nguyen, T. et al. (2006) J. Immunol. 176:7354.

背景介绍

  • Butyrophilin-like 2 (BTNL2) is a member of the BTN/MOG Ig-superfamily and functions as a negative regulator of immune cell activation.BTNL2 is expressed in epithelial cells of the small intestine, colonic dendritic cells, and in cells of the lymph node. BTNL2 expression is upregulated in T cells following activation, a characteristic BTNL2 shares with the homologous B7 family of co-stimulatory molecules. BTNL2 negatively regulates T cells by inhibiting proliferation and inflammatory cytokine secretion. It also increases the expression of FoxP3 in T cells to promote regulatory T cell development. Single nucleotide polymorphisms in BTNL2 are associated with a risk for sporadic prostate cancer, rheumatoid arthritis, sarcoidosis, ulcerative colitis, and other inflammatory diseases.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

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