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产品中心 药物靶点和Fc受体 药物靶点

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CD4/LEU3 Fc Chimera Protein, Human

CD4,LEU3,T4,IMD79,OKT4D

价格 ￥2,520.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010445
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    CD4,LEU3,T4,IMD79,OKT4D

  • Accession

    P01730

  • 表达序列

    Lys26-Trp390, with C-terminal Human IgG1 Fc

  • 表达宿主

    HEK293

  • 分子量

    78-84kDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1、Owen G R. et al. (2016) Human CD4 Metastability Is a Function of the Allosteric Disulfide Bond in Domain 2. Biochemistry. 55(15): 2227-2237.

背景介绍

  • The cluster of differentiation 4 receptor (CD4) is a 55kDa type I integral membrane glycoprotein which plays a substantial role during adaptive immune responses. In T-cells, CD4 mediates maturation, stabilizes T-cell receptor interactions with peptide-major histocompatibility complex class II (MHCII) complexes on antigen presenting cells, and mediates intracellular T-cell signalling.2 In addition to T-cells, CD4 has also been shown to be expressed on monocytes, monocyte-derived macrophages, Langerhans cells, B lymphocytes, dendritic cells, eosinophils, megakaryocytes and mast cells. The role of CD4 during immune function can also be diverted by the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 as the viral receptor utilizes CD4 as the primary receptor as well as the co-receptor CCR5/CXCR4 during the entry process.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

  • ELISA

    • Immobilized CD4/LEU3 Fc Chimera, Human (Cat. No. UA010445) at 2.0μg/mL (100μL/well) can bind Anti-Human CD4 (Ibalizumab) with EC50 of 1.95-2.80 ng/mL.

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