分享产品介绍 评论(0)
物种
Mouse分子别名
FOLR1,FBP,FOLR,FRα,Folate receptor 1,Folate-binding protein 1Accession
P35846表达序列
Thr25-Ser232, with C-terminal 8*His &Avi Tag表达宿主
HEK293分子量
33-43kDa纯度
>95% by SDS-PAGE内毒素含量
<0.1EU/μg标记
Biotin标签
Avi Tag, His Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1、Senol S. et al. (2015) Folate receptor α expression and significance in endometrioid endometrium carcinoma and endometrial hyperplasia. International Journal of Clinical and Experimental Pathology. 8(5): 5633-5641.
Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37-42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. The soluble form of FOLR1 can be shed from the cell surface and into serum and breast milk through protein hydrolysis.
生物活性
Immobilized Folic Acid-BSA at 2.0μg/mL (100μL/well) can bind Biotinylated FOLR1 His&Avi Tag, Mouse (Cat. No. UA010437) with EC50 of 0.17-0.19μg/mL .
电泳
- 1μg (R: reducing conditions, N: non-reducing conditions).
评论(0)