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物种
Human抗原名称
CD7分子别名
CD7,GP40,TP41,LEU-9,Tp40Accession
P09564表达序列
Ala26-Pro180, with C-terminal Human IgG1 Fc表达宿主
HEK293分子量
51-63kDa纯度
>95% by SDS-PAGE内毒素含量
<0.1EU/μg标记
Unconjugated标签
Human Fc Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1、Sempowski G D. et al. (1999) Resistance of CD7-deficient mice to lipopolysaccharide- induced shock syndromes. J Exp Med. 189(6): 1011-1016.
CD7 is a 40-kD member of the Ig gene superfamily that is expressed on a major subset of human peripheral T lymphocytes and NK cells. CD7 is an early T cell activation antigen in that CD7 mRNA levels rise within 15 min after initiation of a transmembrane calcium ion flux. CD7 can complex with CD3 and CD45 molecules, and CD7 signaling involves both protein kinase C and protein tyrosine kinase. CD7 has been shown to be a functional signal-transducing molecule on resting NK cells. Antibody cross-linking of NK cell CD7 induced increases in free cytoplasmic calcium, secretion of IFN-γ, NK cell proliferation, adhesion to fibronectin, and NK cytotoxic activity. Although the above studies have demonstrated in vitro roles for CD7 in T and NK cell activation and/or adhesion, relevant functions of CD7 in vivo remain unknown.
生物活性
Anti-His antibody Immobilized on CM5 Chip captured CD7 Ligand/SECTM1 His Tag, Human(Cat. No. UA010298), can bind CD7 Fc Chimera, Human（Cat. No. UA010411) with an affinity constant of 0.38nM as determined in SPR assay.
电泳
- 1μg (R: reducing conditions, N: non-reducing conditions).
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