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产品中心 药物靶点和Fc受体 药物靶点

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CD7 His Tag Protein, Human

CD7,GP40,TP41,LEU-9,Tp40

价格 ￥2,500.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010396
规格
数量
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产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 抗原名称

    CD7

  • 分子别名

    CD7,GP40,TP41,LEU-9,Tp40

  • Accession

    P09564

  • 表达序列

    Ala26-Pro180, with C-terminal 8*His

  • 表达宿主

    HEK293

  • 分子量

    30-35kDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1、Sempowski G D. et al. (1999) Resistance of CD7-deficient mice to lipopolysaccharide-induced shock syndromes. J Exp Med. 189(6): 1011-1016.

背景介绍

  • CD7 is a 40-kD member of the Ig gene superfamily that is expressed on a major subset of human peripheral T lymphocytes and NK cells. CD7 is an early T cell activation antigen in that CD7 mRNA levels rise within 15 min after initiation of a transmembrane calcium ion flux. CD7 can complex with CD3 and CD45 molecules, and CD7 signaling involves both protein kinase C and protein tyrosine kinase. CD7 has been shown to be a functional signal-transducing molecule on resting NK cells. Antibody cross-linking of NK cell CD7 induced increases in free cytoplasmic calcium, secretion of IFN-γ, NK cell proliferation, adhesion to fibronectin, and NK cytotoxic activity. Although the above studies have demonstrated in vitro roles for CD7 in T and NK cell activation and/or adhesion, relevant functions of CD7 in vivo remain unknown.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • ELISA

    • Immobilized CD7 His Tag Protein, Human (Cat. No. UA010396) at 2.0μg/mL (100μL/well) can bind Grisnilimab (Cat. No. UA011033) with EC50 of 1.22-1.71ng/mL.

  • SPR

    • Protein A Chip captured CD7 Ligand/SECTM1 Fc Chimera, Human (Cat. No. UA010409), can bind CD7 His Tag, Human (Cat. No. UA010396) with an affinity constant of 0.23nM as determined in SPR assay .

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