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产品中心 药物靶点和Fc受体 药物靶点

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TfR/CD71 His Tag Protein, Human

TfR,CD71,TFRC,TFR,sTfR,TfR1,Trfr,T9,p90,transferrin receptor

价格 ￥2,400.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010340
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    TfR,CD71,TFRC,TFR,sTfR,TfR1,Trfr,T9,p90,transferrin receptor

  • Accession

    P02786

  • 表达序列

    Cys89-Phe760, with N-terminal 10* His

  • 表达宿主

    HEK293

  • 分子量

    80-87kDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1、Kawabata H. (2019) Transferrin and transferrin receptors update. Free Radic Biol Med. 133:46-54.

    2、Daniels T R. et al. (2006) The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer. Clin Immunol. 121: 144-158.

    3、Gatter K C. et al. (1983) Transferrin receptors in human tissues: their distribution and possible clinical relevance. J Clin Pathol. 36: 539-545.

背景介绍

  • The major protein essential for the uptake of iron is transferrin receptor (TfR), encoded by TFRC, which is found primarily as a homodimer. TfR is a type II transmembrane glycoprotein that is endocytosed from the cell membrane after binding iron with transferrin (Tf), a serum iron carrier protein. TfR was found to affect many aspects of tumorigenesis, such as cancer cell proliferation, migration, invasion, metastasis and apoptosis. TfR expression was consistent with the asthma severity index, especially the proinflammatory M1 macrophage phenotype. TfR expression may be a good marker to indicate asthma severity. Increased TfR expression and decreased methylation levels of TfR were strongly correlated with multiple clinicopathological parameters. Elevated TfR expression was associated with a poor survival rate in BC patients. TfR is a new independent prognostic biomarker and a potential target for immunotherapy in BC.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

  • ELISA

    • Immobilized TfR/CD71 His Tag Protein, Human (Cat. No. UA010340) at 2 µg/mL (100 µL/well) can bind Biotinylated Transferrin His&Avi Tag Protein, Human with a linear range of 1.9–6.3ng/mL

  • SPR

    • Trontinemab captured on Protein A Chip can bind TfR/CD71 His Tag Protein, Human (Cat. No. UA010340) with an affinity constant of 72.60nM as determined in a SPR assay.

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