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物种
Cynomolgus分子别名
PD-L2,B7-DC,CD273,PDCD1 ligand 2,PDCD1L2,PDCD1LG2Accession
XP_005581839表达序列
Leu20-Pro219, with C-terminal Human IgG1 Fc表达宿主
HEK293分子量
60-75kDa纯度
>95% by SDS-PAGE内毒素含量
<0.1EU/μg标记
Unconjugated性状
Lyophilized Powder缓冲体系
PBS, pH7.4溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1、Kojima M. et al. (2014) Fusion Protein of Mutant B7-DC and Fc Enhances the Antitumor Immune Effect of GM-CSF-secreting Whole-cell Vaccine. J Immunother. 37(3): 147-154.
B7-DC [also known as programmed death ligand 2 (PD-L2)] is a costimulatory molecule expressed predominantly on dendritic cells (DCs) and macrophages. In addition to its coinhibitory receptor, programmed death receptor 1 (PD-1), evidence suggests that B7-DC interacts with an unidentified costimulatory receptor on T cells. B7-DC mutants with selective binding capacity for the costimulatory receptor may be effective in stimulating antitumor immune responses, while avoiding the inhibitory effects of PD-1.
电泳
- 1μg (R: reducing conditions, N: non-reducing conditions).
SPR
Anti-His antibody Immobilized on CM5 Chip captured PD-1 His Tag, Cynomolgus (Cat. No. UA010311), can bind PD-L2/B7-DC Fc Chimera, Cynomolgus (Cat. No. UA010299) with an affinity constant of 0.19 μM as determined in SPR assay.
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