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产品中心 药物靶点和Fc受体 药物靶点

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ROR2 His Tag Protein, Human

ROR2,NTRKR2,Receptor Tyrosine Kinase Like Orphan Receptor 2,BDB1

价格 ￥3,600.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010284
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    ROR2,NTRKR2,Receptor Tyrosine Kinase Like Orphan Receptor 2,BDB1

  • Accession

    A1L4F5

  • 表达序列

    Glu34-Gly403, with C-terminal 8*His EVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGGGGSHHHHHHHH

  • 表达宿主

    HEK293

  • 分子量

    50-60kDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1、Liu Y. et al. (2007) Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3(beta) phosphorylation and promotes osteoblast differentiation and bone formation. Mol Endocrinol. 21: 3050-3061.

    2、Afzal A R. et al. (2000) Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2. Nat Genet. 25: 419-422.

    3、van Bokhoven H. et al. (2000) Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome. Nat Genet. 25: 423-426.

背景介绍
  • Tyrosine-protein kinase transmembrane receptor ROR2 is also known as Neurotrophic tyrosine kinase, receptor-related 2 (NTRKR2), which belongs to the protein kinase superfamily and Tyr protein kinase family and ROR subfamily. ROR2 is broadly expressed during embryonic development and can be found in cells of all three germ layers as well as in most organ tissues. ROR2 binds the Wnt family ligand, Wnt-5a, to activate non-canonical Wnt signaling pathways. Activation of ROR2 signaling promotes cellular proliferation, differentiation, cell-polarization, and migration. ROR2 is important for osteogenic and chondrogenic differentiation of mesenchymal stem cells. ROR2 is also involved in neurite outgrowth and synapse development in the brain.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

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