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产品中心 药物靶点和Fc受体 药物靶点

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Her2 His Tag Protein, Cynomolgus

Her2,ERBB2,CD340,HER-2/neu,MLN19,NEU,NGL,TKR1

价格 ￥3,600.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010241
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Cynomolgus

  • 分子别名

    Her2,ERBB2,CD340,HER-2/neu,MLN19,NEU,NGL,TKR1

  • Accession

    XP_005584091.2

  • 表达序列

    Thr23-Thr652, with C-terminal His

  • 表达宿主

    HEK293

  • 分子量

    85-95kDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1、Krawczyk N. et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-4024.

背景介绍
  • Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2, NEU, NGL, TKR1 and c-erb B2, and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.

  • 生物活性

    • Immobilized Her2 His Tag, Cynomolgus (Cat. No. UA010241) at 5μg/mL (100μL/well) can bind Anti-Human HER2(Trastuzumab) Monoclonal Antibody with EC50 of 2.00 -2.88ng/ ml.
    • Anti-Human HER2(Trastuzumab) Monoclonal Antibody captured on Protein A Biosenor, can bind Her2 His Tag, Cynomolgus (Cat. No. UA010241) with an affinity constant of 1.54 nM as determined in SPR assay.

  • 电泳

    • 2μg (R: reducing conditions, N: non-reducing conditions).

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