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产品中心 药物靶点和Fc受体 药物靶点

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ACVR2A mFc Chimera Protein, Mouse

Activin RIIA,ACTRIIA,Activin receptor type IIA

价格 ￥3,000.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010201
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Mouse

  • 分子别名

    Activin RIIA,ACTRIIA,Activin receptor type IIA,Activin RIIA

  • Accession

    P27038

  • 表达序列

    Ala20-Pro134, with C-mIgG2a Fc

  • 表达宿主

    HEK293

  • 分子量

    45-65kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Mouse Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

背景介绍

  • Activin receptor type-2A (ACVR2A) is also known as Activin receptor type IIA, ACTR-IIA, ACTRIIA and ACVR2, which is single-pass type I membrane protein. They function through heteromeric complexes of type I and type II serine/threonine kinase receptors. Dimeric ligands bind to a type II receptor, such as Activin Receptor IIA (ActRIIA), which then associates with a type I receptor to initiate signal transduction. On ligand binding, ACVR2A forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. ACVR2A is a receptor for activin A, activin B and inhibin A as well. Mature human ActRIIA is a 70 kDa glycoprotein that consists of a 116 amino acid (aa) extracellular domain (ECD), a 26 aa transmembrane segment, and a 352 aa cytoplasmic region that includes the kinase domain and a PDZ-binding motif. Activin proteins are involved in a wide range of biological processes including mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis, the regulation of reproductive physiology, inflammation, and carcinogenesis.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

  • SPR

    • CM5 Chip captured Recombinant Human/Mouse/Rat Activin A, can bind ACVR2A mFc Chimera, Mouse(Cat. No. UA010201) with an affinity constant of 38.25pM as determined in SPR assay.

    • CM5 Chip captured Activin A Protein, Human/Mouse/Rat (Cat. No. UA040343), can bind ACVR2A mFc Chimera, Mouse (Cat. No. UA010201) with an affinity constant of 52.83nM as determined in SPR assay.

    • CM5 Chip captured Activin A Protein, Human (Cat. No. UA040178), can bind ACVR2A mFc Chimera, Mouse (Cat. No. UA010201) with an affinity constant of 37.72nM as determined in SPR assay.

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