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产品中心 药物靶点和Fc受体 药物靶点

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Her2 Fc Chimera Protein, Human

Her2,ERBB2,CD340,HER-2/neu,MLN19,NEU,NG,TKR1

价格 ￥3,600.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010197
规格
数量
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    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Human

    • 分子别名

      Her2,ERBB2,CD340,HER-2/neu,MLN19,NEU,NG,TKR1

    • Accession

      P04626-1

    • 表达序列

      Thr23-Thr652, with C-hIgG1 Fc

    • 表达宿主

      HEK293

    • 分子量

      110-120kDa

    • 纯度

      >95% by SDS-PAGE

    • 内毒素含量

      <0.1EU/μg

    • 标记

      Unconjugated

    • 标签

      Human Fc Tag

    • 性状

      Lyophilized Powder

    • 缓冲体系

      PBS, pH7.4

    • 溶解方法

      Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
      · Please avoid repeated freeze-thaw cycles.

    • 文献引用

      1、Schlessinger J. (2000) Cell Signaling by Receptor Tyrosine Kinases. Cell. 103(2): 211-225.

      2、Codony-Servat J et al. (1999) Cleavage of the HER2 Ectodomain Is a Pervanadate-activable Process That Is Inhibited by the Tissue Inhibitor of Metalloproteases-1 in Breast Cancer Cells. Cancer Res. 59(6): 1196-1201.

    背景介绍

    • The HER2/neu gene is one of the family of genes encoding transmembrane receptors for four growth factors, including the epidermal growth factor receptor (EGFR), HER2/neu, HER3, and HER4. The HER2/neu gene is localized on the long arm (q21) of chromosome 17. This gene codes for a 185 kDa receptor-type tyrosine protein kinase (p185 neu or c-erbB-2) similar to EGFR. This 1255 amino acid transmembrane glycoprotein is composed of three domains: an extracellular factor-binding domain, a transmembrane domain, and an intracellular domain with tyrosine kinase activity. The intracellular domain of HER2/neu has tyrosine kinase activity, which regulates cell growth and proliferation. HER2/neu is over-expressed in 20-25% of invasive breast cancers and is associated with an aggressive tumor, early relapse, and reduced survival.

    • 电泳

      • 1μg (R: reducing conditions, N: non-reducing conditions).

    • ELISA

      • Immobilized Her2 Fc Chimera Protein, Human (Cat. No. UA010197) at 2.0μg/mL (100μL/well) can bind Biotinylated Trastuzumab with EC50 of 1.89-2.32ng/mL.

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