分享产品介绍 评论(0)
物种
Human抗原名称
ACVR2A分子别名
ACVR2,ACTRII,activin A receptor,type IIAccession
P27037表达序列
Ala20-Pro134, with C-hIgG1 Fc表达宿主
HEK293分子量
50-70kDa (Reducing)
纯度
＞95% by SDS-PAGE
内毒素含量
<0.1EU/μg标记
Unconjugated标签
Human Fc Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
ACVR2A (activin A receptor type 2A) belongs to a receptor family that mediates the functions of activins, members of the transforming growth factor-beta (TGF-β) family of ligands with multiple biological functions. The TGF-β signaling pathway is involved in the regulation of cell proliferation, differentiation, migration, and apoptosis of colon cancer. The mutation rate of ACVR2A is approximately 60%, making it the most frequently mutated gene in hypermutated colon cancer. However, the expression profiles of ACVR2A and its biological function in colon cancer tumorigenesis and progression are largely unknown.
生物活性
Protein A Chip captured ACVR2A Fc Chimera, Human (Cat. No. UA010196), can bind Recombinant Human/Mouse/Rat Activin A with an affinity constant of 4.70 pM as determined in SPR assay.
电泳
- 1μg (R: reducing conditions, N: non-reducing conditions).
ELISA
Immobilized Activin A Protein, Human/Mouse/Rat (Cat. No. UA040343) at 1.0μg/mL (100μL/well) can bind ACVR2A Fc Chimera Protein, Human (Cat. No. UA010196) with EC50 of 1.33-2.08ng/mL.
评论(0)