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产品中心 药物靶点和Fc受体 药物靶点

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Her2 His Tag Protein, Human

CD340,ERBB2,NEU,NGL,MLN19,TKR1

价格 ￥2,880.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010176
规格
数量
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    规格：100μg

    价格：￥3,200.00

    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Human

    • 分子别名

      CD340,ERBB2,NEU,NGL,MLN19,TKR1

    • Accession

      P04626-1

    • 表达序列

      Thr23-Thr652, with C-terminal 8*His

    • 表达宿主

      HEK293

    • 分子量

      80-95kDa (Reducing)

    • 纯度

      >95% by SDS-PAGE

    • 内毒素含量

      <0.1EU/μg

    • 标记

      Unconjugated

    • 标签

      His Tag

    • 性状

      Lyophilized Powder

    • 缓冲体系

      PBS, pH7.4

    • 溶解方法

      Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

      · Please avoid repeated freeze-thaw cycles.

    背景介绍

    • Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2, HER-2 /neu, NEU, NGL, TKR1 and c-erb B2, and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. Human ErbB2 consists of 1255 amino acids (aa) including a 22 aa signal sequence, a 630 aa extracellular domain (ECD), a 23 aa transmembrane region, and a 580 aa cytoplasmic domain. HER2 plays a key role in development, cell proliferation and differentiation. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation. Phosphoinositide 3-kinase has been shown to play a role in ErbB2 signal transduction. The cytoplasmic domain of ErbB2 has been shown to associate with beta-catenin and plakoglobin. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation.

    • 生物活性

      • Immobilized Her2 His Tag, Human (Cat. No. UA010176) at 0.5μg/mL (100μL/well) can bind Anti-Human Her2 (Pertuzumab) Monoclonal Antibody with EC50 of 4.6-5.6ng/ ml.

    • 电泳

      • 1μg (R: reducing conditions, N: non-reducing conditions).

    • ELISA

      • Immobilized Her2 His Tag Protein, Human (Cat. No. UA010176) at 2.0μg/mL (100μL/well) can bind Herceptin HER2 Trastuzumab (Cat. No. UA011035) with EC50 of 2.05-2.86ng/mL.

    • SPR

      • Anti-Human HER2(Trastuzumab) Monoclonal Antibody captured on Protein A Biosenor, can bind Her2 His Tag, Human (Cat. No. UA010176) with an affinity constant of 1.35 nM as determined in SPR assay.

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