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Galectin-1 Protein, Human

GBP,HBL,HLBP14,HPL,L-14,Lactose-binding lectin 1,Lectin galactoside-binding soluble 1,lectin,galactoside-binding,soluble,1,LGALS1,Putative MAPK-activating protein PM12,S-Lac lectin 1

价格 ￥300.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010167
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    GBP,HBL,HLBP14,HPL,L-14,Lactose-binding lectin 1,Lectin galactoside-binding soluble 1,lectin,galactoside-binding,soluble,1,LGALS1,Putative MAPK-activating protein PM12,S-Lac lectin 1

  • 表达序列

    Ala2-Asp135

  • 表达宿主

    E.coli

  • 分子量

    14-15kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    20mM Tris, 150mM NaCl, 1mM TCEP, pH8.0

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

背景介绍

  • Galectins are a family of carbohydrate-binding proteins with an affinity for beta-galactosides. Galectin-1 (Gal-1) is differentially expressed by various normal and pathological tissues and appears to be functionally polyvalent, with a wide range of biological activity. The intracellular and extracellular activity of Gal-1 has been described. It preferentially binds Laminin, Fibronectin, Galectin-3BP/MAC-2BP, CD45, CD43, CD7, CD2, CD3, and ganglioside GM1. Galectin-1 modulates cell growth and proliferation, either positively or negatively, depending on the cell type and activation status. It controls cell survival by inducing apoptosis of activated T cells and immature thymocytes. It modulates cytokine secretion by inducing Th2 type cytokines and inhibiting pro-inflammatory cytokine production. Galectin-1 can also modulate cell-cell as well as cell-matrix interactions and depending on the cell type and developmental stage, promote cell attachment or detachment. Galectin-1 has immunosuppressive and anti-inflammatory properties and has been shown to suppress acute and chronic inflammation and autoimmunity.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

  • SPR

    • Anti-His antibody Immobilized on CM5 Chip captured Human CD45, His tag (Cat. No. S0A1014), can bind Galectin-1 Protein, Human (Cat. No. UA010167) with an affinity constant of 8.99μM as determined in SPR assay.

    • Anti-His antibody Immobilized on CM5 Chip captured CD45 His Tag Protein, Human (Cat. No. UA010556), can bind Galectin-1 Protein, Human (Cat. No. UA010167) with an affinity constant of 4.78μM as determined in SPR assay.

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