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物种
Human分子别名
35 kDa Lectin,Carbohydrate-binding protein 35 (CBP 35),Galactose-specific Lectin 3,Galactoside-binding protein (GALBP)表达序列
Ala2-Ile250表达宿主
E.coli分子量
30kDa (Reducing)
纯度
＞95% by SDS-PAGE & RP-HPLC
内毒素含量
<1EU/μg标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4, 2mM DTT溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Galectin-3 (Gal-3) is a member of the galectin family of carbohydrate binding proteins which have affinity for beta-galactoside. Gal-3 is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. Gal-3 can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. Gal-3 is expressed in the nucleus, cytoplasm, mitochondrion, cell surface and extracellular space, and plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation and exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants, Gal-3 plays an important role in the pathogenesis of neuroinflammatory and neurodegenerative disorders, such as multiple sclerosis, Alzheimer's disease, Parkinson's disease, and Huntington's disease. On the other hand, there is also evidence of the protective role of Gal-3 due to its anti-apoptotic effect in target cells.
电泳
- 1μg (R: reducing conditions, N: non-reducing conditions).
ELISA
Immobilized Galectin-3, Human (Cat. No. UA010163) at 2.0μg/mL (100μL/well) can bind Galectin-3 Recombinant Rabbit mAb (SDT-370-78) (Cat. No. S0B3134) with EC50 of 1.43-1.88ng/mL.
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