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ICAM-1/CD54 Fc Chimera Protein, Human

BB2,CD54 antigen,CD54,cell surface glycoprotein P3.58,human rhinovirus receptor,ICAM1,ICAM-1,intercellular adhesion molecule 1 (CD54)

价格 2,600.00 供应商现货 : 3-5个工作日
货号 UA010156
规格
数量
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产品规格
  • 物种

    Human
  • 分子别名

    BB2,CD54 antigen,CD54,cell surface glycoprotein P3.58,human rhinovirus receptor,ICAM1,ICAM-1,intercellular adhesion molecule 1 (CD54)
  • 表达序列

    Gln28-Glu480, with C-terminal Human IgG1 Fc
  • 表达宿主

    HEK293
  • 分子量

    49-72kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg
  • 标记

    Unconjugated
  • 标签

    Human Fc Tag
  • 性状

    Lyophilized Powder
  • 缓冲体系

    PBS, pH7.4
  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.
背景介绍
  • ICAM-1 is a cell-surface glycoprotein and a member of the immunoglobulin (Ig) protein superfamily. ICAM-1 mediates the interaction between keratinocytes and leukocytes. ICAM-1 facilitates a variety of both afferent and efferent immune responses that require intercellular contact and collaboration, including T helper responses, T-dependent B cell responses, antigen-induced T cell proliferation, cell-mediated cytotoxicity, and the binding of leukocytes to vascular endothelium prior to extravasation into inflamed tissue. Pro-inflammatory cytokines interferon-γ and TNF-α stimulate the expression of keratinocyte ICAM-1 and this up-regulation is blocked both in vivo and in vitro if keratinocytes are irradiated with UVB prior to cytokine treatment. In contrast, ICAM-2 is expressed primarily on endothelium and leukocytes (except neutrophils), and its expression generally is not responsive to cytokines. ICAM-3 predominates on thymocytes and resting lymphocytes, which are low in ICAM-1. When neutrophils are activated, they shed the majority of their ICAM-3 into the medium by proteolytic cleavage. In some reports, the expression of ICAM-1 has been positively correlated with a more aggressive tumor phenotype and metastatic potential. For instance, the invasiveness of breast cancer cells has been positively correlated with the expression of ICAM-1. Also, it has been suggested that an ICAM-1–ICAM-1 homophilic interaction between breast cancer cells and mesenchymal stem cells in bone marrow mediates the metastatic expansion of cancer cells, displacing hematopoietic stem cells from their niche.

  • 电泳

    • 2μg (R: reducing conditions, N: non-reducing conditions).
  • ELISA

    • Immobilized ICAM-1/CD54 Fc Chimera, Human (Cat. No. UA010156) at 2.0μg/mL (100μL/well) can bind ICAM-1/CD54 Recombinant Rabbit mAb (S-906-48) (S-1233-25) (Cat. No. S0B0795) with EC50 of 1.62-2.20ng/mL.

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