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产品中心 药物靶点和Fc受体 药物靶点

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FGF-R2 (IIIb) His Tag Protein, Human

价格 ￥2,800.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010145
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • Accession

    P21802-3

  • 表达序列

    Pro154-Leu358, with C-terminal 10*His

  • 表达宿主

    HEK293

  • 分子量

    41-60kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.
背景介绍

  • FGF-R2(IIIb) (fibroblast growth factor receptor 2, isoform IIIb) is a tyrosine kinase receptor present in many types of epithelial cells. This receptor is recognized and activated by specific peptide growth factors (Fgf1, Fgf3, Fgf7 and Fgf10) expressed in the mesenchyme. Interactions of Fgfr2 with its cognate ligands mediate epithelium-mesenchyme cross-talk and are involved in important processes of organogenesis. Within the gonad, the isoform FGFR2c acts as the receptor for FGF9 in order to suppress ovarian gene expression (WNT4). Its expression, like FGF9, is regulated by SOX9. FGFR2 mutations have been associated with multiple syndromes including Crouzon syndrome, Jackson–Weiss syndrome, LADD syndrome and Pfeiffer syndrome. FGFR-2 is also found in a wide variety of cell types and tissues and was first identified as an amplified gene from a human gastric cancer cell line. Amplification of Fgfr2 on chromosome 10q26 is observed in about 10% of gastric cancers, as well as in breast and oral squamous cell carcinomas.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

  • SPR

    • Anti-His antibody Immobilized on CM5 Chip captured FGF-R2 (IIIb) His Tag, Human (Cat. No. UA010145), can bind KGF/FGF-7, Human (Cat. No. UA040040) with an affinity constant of 0.19μM as determined in SPR assay.

    • CM5 Chip captured FGF-9, Human(Cat. No. UA040087), can bind FGF-R2 (IIIb) His Tag, Human(Cat. No. UA010145) with an affinity constant of 0.45μM as determined in SPR assay.

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