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产品中心 药物靶点和Fc受体 药物靶点

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MFI2/CD228 His Tag Protein, Human

价格 ￥3,200.00 （ 1-2周）
货号 UA010134
规格
数量
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产品介绍 评论(0)

产品规格

  • 物种

    Human

  • Accession

    P08582

  • 表达序列

    Gly20-Cys709, with C-terminal 8*His

  • 表达宿主

    HEK293

  • 分子量

    90kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE&RP-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 稀释度

背景介绍

  • MELTF (Melanotransferrin, also known as MFI2, CD228) is a cell-surface glycoprotein found on melanoma cells. MELTF is a member of the transferrin (Tf) family of iron (Fe)-binding proteins that was first identified as a cell-surface marker of melanoma. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. siRNA-mediated CD228 knockdown increased the expression of the transcription factor DLX5 and enhanced osteogenesis of human bone marrow-derived mesenchymal stem cells (hBM-MSC) evidenced by an increased expression of the runt-related transcription factor 2 (RUNX2), osterix (Osx), and osteocalcin (OC), as well as higher alkaline phosphatase (ALP) activity and extracellular calcium deposition.

  • 电泳

    • 2μg (R: reducing conditions, N: non-reducing conditions).

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