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产品中心 药物靶点和Fc受体 药物靶点

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IL-3 Rα/CD123 Fc Chimera Protein, Human

价格 ￥2,450.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010120
规格
数量
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    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Human

    • Accession

      P26951-1

    • 表达序列

      Thr19-Arg305, with C-terminal Human hIgG1 Fc

    • 表达宿主

      HEK293

    • 分子量

      72-95kDa (Reducing)

    • 纯度

      >95% by SDS-PAGE

    • 内毒素含量

      <0.1EU/μg

    • 标记

      Unconjugated

    • 标签

      Human Fc Tag

    • 性状

      Lyophilized Powder

    • 缓冲体系

      PBS, pH7.4

    • 溶解方法

      Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

      · Please avoid repeated freeze-thaw cycles.

    背景介绍

    • Human IL-3 Rα is expressed from human 293 cells. It contains AA Thr19 - Arg305. This protein carries a polyhistidine tag at the C-terminus. Interleukin 3 receptor alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123) is a 45-62kDa glycoprotein member of the hematopoietin receptor superfamily. This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to form a high-affinity receptor for IL-3. The interleukin-3 receptor α chain (CD123) has been identified as a potential immunotherapeutic target because it is overexpressed in AML compared with normal hematopoietic stem cells.

    • 生物活性

      • IL-3 Rα/CD123 Fc Chimera, Human (Cat. No. UA010120) captured on Protein A Biosenor, can bind IL-3, Human (Cat. No. UA040008) with an affinity constant of 0.16 μM as determined in SPR assay.

    • 电泳

      • 1μg (R: reducing conditions, N: non-reducing conditions).

    • SPR

      • Protein A Chip captured IL-3 Rα/CD123 Fc Chimera Protein, Human (Cat. No. UA010120), can bind IL-3, Human (Cat. No. UA040068) with an affinity constant of 0.16μM as determined in SPR assay.

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