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产品中心 药物靶点和Fc受体 药物靶点

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LAG-3/CD223 His Tag Protein, Human

价格 ￥2,700.00 （ 1-2周）
货号 UA010102
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • Accession

    P18627

  • 表达序列

    Leu23-Leu450, with C-terminal 8*His

  • 表达宿主

    HEK293

  • 分子量

    55-65kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.
背景介绍

  • Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. The LAG3 is Biased expression in spleen (RPKM 15.1), lymph node (RPKM 8.3) and 12 other tissues. Lymphocyte activation gene 3 (LAG3) is an inhibitory checkpoint protein expressed on activated T effector, T regulatory, and natural killer cells. The main function of LAG3 is the regulation of immune homeostasis.Several studies have suggested its role in malignant and autoimmune diseases.

  • 生物活性

    • Immobilized LAG-3/CD223 His Tag, Human (Cat. No. UA010102) at 1.5μg/mL (100μL/well) can bind FGL1 Fc Chimera, Human (Cat. No. UA010251) with EC50 of 0.29-0.38μg/ml.
    • Immobilized LAG-3/CD223 His Tag, Human (Cat. No. UA010102) at 1.0μg/mL (100μL/well) can bind FGL1 Fc Chimera, Cynomolgus (Cat. No. UA010248) with EC50 of 0.36-0.56μg/ml.

  • 电泳

    • 2μg (R: reducing conditions, N: non-reducing conditions).

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