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LILRA2 His Tag Protein, Human

CD85H,LIR7

价格 ￥3,600.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010099
规格
数量
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    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Human

    • 分子别名

      CD85H,LIR7

    • Accession

      Q8N149-1

    • 表达序列

      Gly24-Asn449, with C-terminal 8*His

    • 表达宿主

      HEK293

    • 分子量

      70-90kDa (Reducing)

    • 纯度

      >95% by SDS-PAGE

    • 内毒素含量

      <0.1EU/μg

    • 标记

      Unconjugated

    • 标签

      His Tag

    • 性状

      Lyophilized Powder

    • 缓冲体系

      PBS, pH7.4

    • 溶解方法

      Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
      · Please avoid repeated freeze-thaw cycles.
    背景介绍

    • Leukocyte immunoglobulin-like receptors (LILRs) are inhibitory, stimulatory or soluble receptors encoded within the leukocyte receptor complex. LILRs includes activating (LILRA1, LILRA2, LILRA3) and inhibitory (LILRB1, LILRB2, LILRB3, LILRB4, LILRB5) isoforms. LILRA2, also known as CD85H and LIR7 (Leukocyte immunoglobulin-like receptor 7), is expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. It consists of 2-4 extracellular Ig-like domains, a transmembrane domain (TM), and a short cytoplasmic tail. LILRA2 contains 4 Ig-like C2 type domains in the extracellular region. LILRA2 was recently reported to bind to other unique ligands, the bacterially degraded Igs (N-truncated Igs), for the activation of immune cells.

    • 电泳

      • 2μg（R: reducing conditions, N: non-reducing conditions).

    • ELISA

      • Immobilized LILRA2 His Tag Protein, Human (Cat. No. UA010099) at 2.0μg/mL (100μL/well) can bind LILRA2 Recombinant Rabbit mAb (S-287-234) (Cat. No. S0B0643) with EC50 of 10.66-17.20ng/mL.

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