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产品中心 药物靶点和Fc受体 药物靶点

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Siglec-5 His Tag Protein, Human

Sialic acid-binding immunoglobulin-like lectins 5

价格 ￥3,040.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010074
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Sialic acid-binding immunoglobulin-like lectins 5

  • Accession

    O15389

  • 表达序列

    Glu17-Thr434, with C-terminal 8*His

  • 表达宿主

    HEK293

  • 分子量

    71-78kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

背景介绍

  • Sialic acid-binding immunoglobulin-like lectins (Siglecs) are cell surface receptors of the I-type lectin family that are expressed on innate immune cells and bind to sialylated and non-sialylated ligands.These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. Siglec-5 is Biased expression in bone marrow (RPKM 12.5), spleen (RPKM 10.6) and 12 other tissues. Siglec-5 is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.

  • 电泳

    • 1μg（R: reducing conditions, N: non-reducing conditions).

  • ELISA

    • Immobilized Siglec-5 His Tag Protein, Human (Cat. No. UA010074) at 2.0μg/mL (100μL/well) can bind SIGLEC5 Rabbit pAb with EC50 of 4.84-9.00 ng/mL.

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