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产品中心 药物靶点和Fc受体 药物靶点

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CD73 His Tag Protein, Human

价格 ￥6,800.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010067
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数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • Accession

    P21589-1

  • 表达序列

    Trp27-Ser549, with C-terminal 10*His

  • 表达宿主

    HEK293

  • 分子量

    60-72 kDa(Reducing)

  • 纯度

    ＞90% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.
背景介绍

  • CD73, also known as ecto‐5′‐nucleotidase (NT5E), is a glycosylphosphatidylinositol (GPI)‐anchored protein encoded by the gene NT5E, reacts on the surface of immune cells, stromal cells and cancer cells. It is a part of the extracellular enzymatic mechanism that regulates the conversion of extracellular ATP to adenosine. CD73 undergoes N-linked glycosylation, disulfide bond-mediated homodimerization, and membrane association via a glycosylphosphatidylinositol (GPI) anchor. CD73 is involved in ATP metabolism, which cooperates with CD39 to generate anti‐inflammatory adenosine from pro‐inflammatory ATP. CD73 regulates tissue homeostasis and pathophysiological responses related to immunity, inflammation, and cancer.

  • 电泳

    • 1μg（R: reducing conditions, N: non-reducing conditions).

  • ELISA

    • Immobilized CD73 His Tag, Human (Cat. No. UA010067) at 2.0μg/mL (100μL/well) can bind Anti-Human CD73 Monoclonal Antibody (Oleclumab) with EC50 of 1.12-1.26ng/mL.

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