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产品中心 药物靶点和Fc受体 药物靶点

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GIPR His Tag Protein, Human

价格 ￥3,800.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010066
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • Accession

    P48546-1

  • 表达序列

    Arg22-Gln138, with C-terminal 8*His

  • 表达宿主

    HEK293

  • 分子量

    25-34 kDa(Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

背景介绍

  • Glucose-dependent insulinotropic polypeptide receptor (GIPR) are G protein-coupled receptors belonging to the secretin receptor super-family, also known as class B1. GIPR comprises an N-terminal extracellular domain (ECD), a central domain consisting of seven transmembrane α-helices, and a C-terminal, cytoplasmic domain that mediates intracellular signal transduction by physical association with the G protein. GIPR increases insulin secretion in hyperglycemia and stimulates glucagon release in hypoglycemia. It also plays an important role in adipogenesis, islet β cell proliferation and insulin release, and is associated with type 2 diabetes, obesity and neurodegenerative diseases.

  • 电泳

    • Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • ELISA

    • Immobilized GIPR His Tag Protein, Human (Cat. No. UA010066) at 2.0μg/mL (100μL/well) can bind Biotinylated Anti-GIPR(maridebart biosimilar) mAb with EC50 of 0.6-1.1 ng/ mL.

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