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产品中心 药物靶点和Fc受体 药物靶点

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ICOS/CD278 Fc Chimera Protein, Mouse

价格 ￥2,700.00 （ 1-2周）
货号 UA010065
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Mouse

  • Accession

    Q9WVS0

  • 表达序列

    Glu21-Leu144, with C-terminal human IgG Fc

  • 表达宿主

    HEK293

  • 分子量

    50-60 kDa(Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.
背景介绍

  • ICOS (The inducible T cell co-stimulator) belongs to the CD28 family of co-stimulatory molecules, and it is selectively expressed by activated T-cells, while its ligand is constitutively present on the surface of a variety of cells including dendritic cells, macrophages, B-cells but also on endothelial cells, lung epithelial cells and fibroblasts. ICOS has been implicated in various immune outcomes, including the induction and regulation of Th1, Th2, and Th17 immunity. The triggering of ICOS on T-cells by ICOSL has been shown to modulate lymphocyte cytokine secretion pattern and, in some conditions, to favour regulatory T- cell (Treg) differentiation. ICOS cooperate in a nonredundant manner to maximize and sustain Th cell immune responses. In addition, ICOS/ICOSL Interaction plays an important role in the development and differentiation of Follicular T-helper cells (Tfh) in the germinal centres of lymphatic nodes. Mouse and human ICOS share approximately 72% amino acid identity.

  • 生物活性

    • Immobilized B7-H2/ICOSLG His Tag, Human (Cat. No. UA010058) at 2μg/mL (100μL/well) can bind ICOS/CD278 Fc Chimera, Mouse (Cat. No. UA010065) with EC50 of 0.197μg/mL.

  • 电泳

    • 1μg（R: reducing conditions, N: non-reducing conditions).

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