热搜词：
注册
登录
CN
  • CN
  • EN

产品中心 药物靶点和Fc受体 药物靶点

所有图片（1/2）

B7-H2/ICOSLG His Tag Protein, Human

价格 ￥2,100.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010058
规格
数量
收藏 分享

关联产品推荐

  • B7-H6/NCR3LG1 His Tag Protein, Human

    规格：100μg

    价格：￥2,700.00

  • B7-H4 His Tag Protein, Cynomolyus

    规格：100μg

    价格：￥2,800.00

  • B7-H2/ICOSLG His Tag Protein, Human

    规格：100μg

    价格：￥2,100.00

  • B7-H5/VISTA His Tag Protein, Mouse

    规格：100μg

    价格：￥3,100.00

  • B7-H5/VISTA His Tag Protein, Human

    规格：100μg

    价格：￥3,100.00

  • B7-H6/NCR3LG1 Fc Chimera Protein, Human

    规格：100μg

    价格：￥2,600.00

  • B7-1/CD80 Fc Chimera Protein, Human

    规格：100μg

    价格：￥3,000.00

  • B7-H3/CD276 His Tag Protein, Human

    规格：25μg

    价格：￥800.00

    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Human

    • Accession

      O75144

    • 表达序列

      Asp19-Ser258, with C-terminal 8*His

    • 表达宿主

      HEK293

    • 分子量

      45-56 kDa(Reducing)

    • 纯度

      ＞95% by SDS-PAGE

    • 内毒素含量

      <0.1EU/μg

    • 标记

      Unconjugated

    • 性状

      Lyophilized Powder

    • 缓冲体系

      PBS, pH7.4

    • 溶解方法

      Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

      · Please avoid repeated freeze-thaw cycles.

    背景介绍

    • ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by costimulating memory T-cell function.

    • 电泳

      • 2μg（R: reducing conditions, N: non-reducing conditions).

    • ELISA

      • Immobilized ICOS/CD278 Fc Chimera, Human (Cat. No. UA010053) at 1μg/mL (100μL/well) can bind B7-H2/ICOSLG His Tag, Human (Cat. No. UA010058) with EC50 of 8.74-10.7ng/mL.

    评论(0)