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产品中心 药物靶点和Fc受体 药物靶点

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B7-H4 His Tag Protein, Cynomolyus

VTCN1

价格 ￥2,800.00 （ 1-2周）
货号 UA010057
规格
数量
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    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Cynomolgus

    • 分子别名

      VTCN1

    • Accession

      Q7Z7D3-1

    • 表达序列

      Phe29-Ala258, with C-terminal 8*His

    • 表达宿主

      HEK293

    • 分子量

      45-57 kDa(Reducing)

    • 纯度

      ＞95% by SDS-PAGE

    • 内毒素含量

      <0.1EU/μg

    • 标记

      Unconjugated

    • 性状

      Lyophilized Powder

    • 缓冲体系

      PBS, pH7.4

    • 溶解方法

      Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
      · Please avoid repeated freeze-thaw cycles.
    背景介绍

    • V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1/B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.

    • 电泳

      • 2μg（R: reducing conditions, N: non-reducing conditions).

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