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产品中心 药物靶点和Fc受体 药物靶点

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B7-H6/NCR3LG1 His Tag Protein, Human

价格 ￥2,700.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010054
规格
数量
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    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Human

    • Accession

      Q68D85

    • 表达序列

      Asp25-Ser262, with C-10*His

    • 表达宿主

      HEK293

    • 分子量

      Predicted MW: 28.4 kDa Observed MW: 35-55 kDa

    • 纯度

      ＞95% by SDS-PAGE

    • 内毒素含量

      <1EU/μg

    • 活性

      Immobilized Human B7-H6, His tag at 20 μg/mL (50 μL/well) can bind NKp30/CD337 Fc Chimera, Human (UA010046) with EC50 of 0.014-0.022 μg/ml.

    • 标记

      Unconjugated

    • 性状

      Lyophilized Powder

    • 缓冲体系

      0.2M PBS, pH7.4.

    • 溶解方法

      Reconstitute at 0.1-1mg/mL according to the size in ultrapure water after rapid centrifugation.

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

      · Please avoid repeated freeze-thaw cycles.

    背景介绍

    • B7-H6 (encoded by gene NCR3LG1) is a type I transmembrane protein of B7 family. It consists of two extracellular Ig-like domains (IgV and IgC), an α-helical transmembrane domain, and a C-terminal sequence homologous to group-specific antigen (GAG) proteins. This C-terminal sequence has various signaling motifs, including ITIM-, SH-2-, and SH-3-binding motifs. B7-H6 can bind its receptor NKp30 to exert anti-tumor effects by helping NK cells to recognize abnormal cells. B7-H6 is expressed in several tumor cell lines, both in vitro and in vivo, including esophageal squamous cell carcinoma, oral squamous cell carcinoma and breast cancer. but remains undetected in healthy cells thus far, and is therefore an excellent tumor marker. In recent years, B7-H6 expression has been reported to be upregulated in certain cancers and to be associated with tumor differentiation, stage and progression.

    • 生物活性

      • Immobilized Human B7-H6, His tag at 20 μg/mL (50 μL/well) can bind NKp30/CD337 Fc Chimera, Human (UA010046) with EC50 of 0.014-0.022 μg/ml.

    • 电泳

      • 2μg（R: reducing conditions).

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