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GCGR Fc Chimera Protein, Human
规格：100μg
价格：￥6,800.00
GCGR His Tag Protein, Human
规格：100μg
价格：￥6,800.00
产品介绍 评论(0)
物种
HumanAccession
P47871-1表达序列
Ala26-Lys136, with C-terminal 8*His表达宿主
HEK293分子量
33-43 kDa(Reducing)
纯度
＞95% by SDS-PAGE
内毒素含量
<0.1EU/μg标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
The glucagon receptor (GCGR) is a Class B GPCR that has an important role in maintenance of glucose homeostasis and, as such, is considered to be a valuable target for the treatment of diabetes. The GCGR is widely expressed and can be found in the liver, adipose tissue, heart, kidney, pancreatic islets, stomach, small intestine, thyroid, and skeletal muscle. The GCGR is coupled to the activation of adenylate cyclase via Gs, with concomitant rise in cellular cyclic AMP levels and activation of protein kinase A (PKA). GCGR mRNA has been detected in islets. In vitro/ex vivo studies suggest that glucagon potentiates insulin secretion from isolated islets, although the potency is considerably less than that of the insulin secretagogue GLP-1. Mutations of the GCGR gene are associated with congenital noninsulin-dependent diabetes, and inhibition of GCGR in vivo lowers blood glucose and improves glucose tolerance in obese diabetic mice.
电泳
- 2μg (R: reducing conditions, N: non-reducing conditions).
ELISA
Immobilized Crotedumab (Cat. No. UA011042) at 2.0μg/mL (100μL/well) can bind GCGR His Tag Protein, Human(Cat. No. UA010052) with EC50 of 3.54-3.92ng/ mL.
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