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产品中心 药物靶点和Fc受体 药物靶点

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B7-H5/VISTA His Tag Protein, Human

价格 ￥3,100.00 （ 1-2周）
货号 UA010040
规格
数量
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    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Human

    • Accession

      AAH20568

    • 表达序列

      Phe33-Ala194, with C-terminal 8*His FKVATPYSLYVCPEGQNVTLTCRLLGPVDKGHDVTFYKTWYRSSRGEVQTCSERRPIRNLTFQDLHLHHGGHQAANTSHDLAQRHGLESASDHHGNFSITMRNLTLLDSGLYCCLVVEIRHHHSEHRVHGAMELQVQTGKDAPSNCVVYPSSSQESENITAAGGGSHHHHHHHH

    • 表达宿主

      HEK293

    • 分子量

      28-43 kDa(Reducing)

    • 纯度

      >95% by SDS-PAGE

    • 内毒素含量

      <0.1EU/μg

    • 标记

      Unconjugated

    • 标签

      His Tag

    • 性状

      Lyophilized Powder

    • 缓冲体系

      PBS, pH7.4

    • 溶解方法

      Reconstitute at 0.1-1mg/mL according to the size in ultrapure water after rapid centrifugation.

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

      · Please avoid repeated freeze-thaw cycles.

    背景介绍

    • B7-H5, also known as VISTA, is one of the negative immune checkpoints of the B7 family. B7-H5 which is the most conserved among the B7 membersis mainly expressed in myeloid cells such as macrophages, monocytes, dendritic cells, and T cells VISTA is a type I transmembrane protein consisting of a single N-terminal immunoglobulin (Ig) V domain, an approximately 30 amino acid (aa) stalk, a transmembrane domain, and a 95 aa cytoplasmic tail. It can regulate a variety of immune cells, including B cells, T cells, and endothelial cells by binding to its putative receptor(s) on these cells. The expression of B7-H5 is closely related to the diagnosis, severity and prognosis of tumors.

    • 电泳

      • 2 μg（R: reducing conditions, N: non-reducing conditions)

    • SPR

      • Protein G Chip captured VSIG3/IGSF11 Fc Chimera Protein, Human (Cat. No. UA010571), can bind B7-H5/VISTA His Tag Protein, Human (Cat. No. UA010040) with an affinity constant of 0.43μM as determined in SPR assay.

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